Process for the preparation of a pasteurized immunoglobulin prep

Details Process for the preparation of a pasteurized immunoglobulin prep Process for the preparation of a pasteurized immunoglobulin prep

1992-12-10

1993-09-28

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303871, 5303905, 424 858, C07K 1514, A61K 39395

Patent

active

052487679

ABSTRACT:
A process for the production of a pasteurized immunoglobulin preparation is described, which comprises heating a solution of an immunoglobulin in the presence of a carboxylic acid or one of its salts and/or of a saccharide until viable pathogens, which may remain undetected in conventional tests, in particular hepatitis viruses or HTLV III ("Aids") viruses, are inactivated i.e. are rendered incapable of reproduction and/or of being intracellularly or otherwise reproduced.
A preparation of this type can be used for therapy or prophylaxis or as component of a diagnostic kit.

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patent: 4164495 (1979-08-01), Hansen
patent: 4579735 (1986-04-01), Heimburger et al.
patent: 4640834 (1987-02-01), Eibl et al.
patent: 4687664 (1987-08-01), Philapitsch et al.
patent: 4721777 (1988-01-01), Uemura et al.
patent: 4762714 (1988-08-01), Mitra et al.
Abstract of Japanese 042917, Sep. 1983, Green Cross.
Noller, Chemistry of Organic Compounds (1957), pp. 412-413.
The Condensed Chemical Dictionary, Eighth Edition, Revised by Gessner G. Hawley, Van Nostrand Reinhold Company (1971) p. 833.

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