Process for the preparation of a highly pure pharmaceutical...

Details Process for the preparation of a highly pure pharmaceutical... Process for the preparation of a highly pure pharmaceutical...

2005-06-07

2005-06-07

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C560S051000, C560S052000, C562S555000

Reexamination Certificate

active

06903232

ABSTRACT:
This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-α,α-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-α,α-dimethylphenylacetic acid of Formula IIis decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.

REFERENCES:
patent: 5581011 (1996-12-01), D'Ambra
patent: 5663412 (1997-09-01), D'Ambra

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