Process for the preparation of a growth hormone secretagogue

Details Process for the preparation of a growth hormone secretagogue Process for the preparation of a growth hormone secretagogue

1996-10-23

1998-03-03

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 17, C07D45100

Patent

active

057236160

ABSTRACT:
The present invention is directed to a novel process for the preparation of the compound yl)carbonyl!-2-(phenylmethyl-oxy)ethyl!-2-amino-2-methyl-propanamide, and salts thereof, which has the structure: ##STR1## and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.

REFERENCES:
patent: 5536716 (1996-07-01), Meng-Hsin Chen et al.
Sumitomo Seiyaku "Cell adhesion peptide for suppression of cancer metastasis and platelet aggretion" Derwint Abst. 94-077374, 1994.
Sole et al. "Mixed anhydrides in peptide synthesis . . . " Tetrahedron vo.42, pp.193-198, 1986.
A.A. Patchet, et al, Proc. Natl. Acad. Sci. USA, vol. 92, pp. 7001-7005 (Jul. 1995).
Ioannis Houpis, et al, "Synthesis of the Orally Active Nonpeptidal Growth Hormone Secretagogue, MK-677", Presentation at Gordon Research Conference, New Hampton, NH (Jul. 14, 1996).

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