Process for the preparation of a cephalosporin antibiotic

Details Process for the preparation of a cephalosporin antibiotic Process for the preparation of a cephalosporin antibiotic

1994-12-19

1997-01-14

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50156

Patent

active

055941290

ABSTRACT:
The present invention provides an anhydrous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA..sup.2 isomer comprising the N-acylation of a silylated derivative of 7-amino-3-[(1-methyl-1-pyrrolidinio)-methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.

REFERENCES:
patent: 4203899 (1980-05-01), Ochiai et al.
patent: 4385181 (1983-05-01), Farge et al.
patent: 4406899 (1983-09-01), Aburaki et al.
patent: 4754031 (1988-06-01), Angerbauer et al.
patent: 4868294 (1989-09-01), Brundidge et al.
patent: 4910301 (1990-03-01), Kaplan et al.
patent: 4943631 (1990-07-01), Looker
Chemical Abstracts vol. 110, 389,79d p. 544 (1989).

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