Process for the preparation of a carbocyclic nucleoside analogue

Details Process for the preparation of a carbocyclic nucleoside analogue Process for the preparation of a carbocyclic nucleoside analogue

1990-07-18

1992-05-05

Rivers, Diana

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544251, 544277, C07D47318, C07D47332

Patent

active

051109263

ABSTRACT:
A process is described for the preparation of carbocyclic guanosine from aristeromycin in a multi-step procedure, the final step of which is the hydrolysis of a compound of the formula ##STR1## wherein R.sup.1 represents a C.sub.1-6 alkyl group or an arylC.sub.1-4 alkyl group and R.sup.2, R.sup.3 and R.sup.4 each independently represent a hydrogen atom or a hydroxyl protecting group.
Carbocyclic guanosine is an intermediate in the synthesis of carbocyclic analogues of nucleosides having use in therapy, particularly as antiviral agents.

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patent: 4954504 (1990-09-01), Chen et al.
Ueda, et al., Chemical Abstracts, vol. 86: 5767r (1977).
Kikkoman Shoyu Co., Ltd., Chemical Abstracts, vol. 94: 140122g (1981).
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Miura et al, Chem. Pharm. Bull., 23(2), 464-466 (1975).
Biggadike et al., J. Chem. Soc. Chem. Commun., 14, 1083-1084 (1987).
Shealy et al, J. Med. Chem., 27, 670-674 (1984).
Shealy et al, J. Pharm. Sci., 62(9), 1432-1434 (1973).

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