Process for the preparation of a biologically active substance f

Details Process for the preparation of a biologically active substance f Process for the preparation of a biologically active substance f

1981-01-08

1983-05-24

Lieberman, Allan

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424101, C07G 700

Patent

active

043849911

ABSTRACT:
The invention relates to a process for the preparation of a biologically active substance, which can be isolated from normal white blood cells and is capable of inhibiting the proliferation of normal and leukemic myeloid cells selectively.
The substance obtained is a peptide, which has an amino acid composition of Tau.sub.1, Asx.sub.1, Ser.sub.2, Thr.sub.1, Glx.sub.3, Gly.sub.2, Ala.sub.1, (PO.sub.4).sub.1.sup.2-, a negative charge at pH 6.5, an electrophoretic mobility of -0.55 to -0.65 related to aspartic acid, has no charge at pH 1.9, has a mobility of about 0.26 related to .epsilon.-DNP-lysine and gives a positive chloro-toluidine reaction.

REFERENCES:
patent: 4294824 (1981-10-01), Jones
Chem. Abst.: 86:39580q, 90:163664s, 93:24173e, 93:63891g.
Paukovits, W. R. Chem. Abs. 85:189853z.
Rytomaa, T. Chem. Abs. 81:73662z.

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