Process for the preparation of a 2-oxopyrrolidine compound

Details Process for the preparation of a 2-oxopyrrolidine compound Process for the preparation of a 2-oxopyrrolidine compound

1999-03-02

1999-11-16

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20714

Patent

active

059861070

ABSTRACT:
A process for producing a lactam of the formula ##STR1## wherein 2-bromo-4 chloro butyryl bromide or 2,4-dibromo butyryl bromide is coupled with 4-aminobenzonitrile to produce 4-(2,4-bromobutyrylamino)-benzonitrile, which is combined with sodium hydroxide, potassium hydroxide or potassium carbonate to produce 4-(3-bromo-2-oxopyrrolidin-1-yl)benzonitrile which is subjected to an excess of ammonium hydroxide to produce compounds of the formula (I).

REFERENCES:
patent: 5484946 (1996-01-01), Abood et al.

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