Process for the preparation of a 2-alkyl-4-amino-5-aminomethylpy

Details Process for the preparation of a 2-alkyl-4-amino-5-aminomethylpy Process for the preparation of a 2-alkyl-4-amino-5-aminomethylpy

1983-01-26

1985-09-03

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

564397, 564398, 564472, 564473, C07D23902

Patent

active

045394032

ABSTRACT:
There is disclosed a process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine, which comprises subjecting a 2-alkyl-4-amino-5-formylpyrimidine to catalytic reaction with hydrogen and ammonia in the presence of a reduction catalyst.
According to the process of this invention, the desired product can be obtained in much higher yield as compared with the processes known to the art.

REFERENCES:
patent: 3223734 (1965-12-01), Fallstad
patent: 4210605 (1980-07-01), Hoshino
Groggins, Unit Process in Organic Synthesis, 5th Edition, pp. 408-409, 1958.
Morrison, Organic Chemistry, p. 733.
Huber, J.A.C.S. 66,876, 1944.

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