Process for the preparation of...

Details Process for the preparation of... Process for the preparation of...

2006-12-19

2006-12-19

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07151179

ABSTRACT:
The key intermediate in any synthesis of Irinotecan is 7-ethyl-10-hydroxy-20(S)-camptothecin. A process for the efficient synthesis of this intermediate is demonstrated proceeding through readily available 20(S)-camptothecin. Various other tecan compounds may be made by use of corresponding 7-alkyl-10-hydroxy-20(S)-camptothecin intermediates.

REFERENCES:
patent: 5734056 (1998-03-01), Burk et al.
Sawada et al, Chemical and Pharmaceutical Bulletin, 39(12), pp. 3183-3188 (1991).

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