Process for the preparation of 9-β-anomeric nucleoside...

Details Process for the preparation of 9-β-anomeric nucleoside... Process for the preparation of 9-β-anomeric nucleoside...

2005-04-26

2005-04-26

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S027110, C536S022100, C536S055300, C536S024500, C536S025300, C536S027810, C536S023100, C536S028500, C536S028100, C536S028520, C536S028550, C536S026230, C536S025320, C536S025310, C536S026600, C536S026710, C536S027600, C536S027300, C536S028400, C514S043000, C514S045000, C435S006120, C435S089000, C544S277000

Reexamination Certificate

active

06884880

ABSTRACT:
A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-β-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-β-fluoro and 2′,3′-dideoxy-2′-β-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.

REFERENCES:
patent: 4189581 (1980-02-01), Scharwaechter et al.
patent: 4760137 (1988-07-01), Robins et al.
patent: 5459255 (1995-10-01), Cook et al.
patent: 5821357 (1998-10-01), Chou et al.
patent: 351795 (1990-01-01), None
J. Med. Chem. 33, 978 (1990).
J.A.C.S. 105, 4059 (1983).
Robins et al., J.A.C.S. 106 6379 (1984).
J. Med. Chem. 37, 821 (1994).
J. Med. Chem. 34, 1647 (1991).
Ikehara, M., et al., J. Amer. Chem. Soc. 87:3 (1965).
Communications to the Editor, vol. 85, p. 2344 (1963).
Furukawa, Y., et al., Chem. Pharm. Bull. 16(6) 1076-1080 (1968).
Cancer Res. 42, 3911 (1982).
Suhadolnik, R.J., Nucleoside Antibiotics: New York Wiley-Interscience.
J. Med. Chem. 35, 397 (1992).

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