Process for the preparation of 9-deazaguanine derivatives

Details Process for the preparation of 9-deazaguanine derivatives Process for the preparation of 9-deazaguanine derivatives

2005-09-20

2005-09-20

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C548S532000

Reexamination Certificate

active

06946554

ABSTRACT:
Derivatives of 9-deazaguanine of the formula I:are prepared by reacting an aldehyde or ketone of the formula II:with a dialkylaminomalonate to produce an enamine. The enamine is then reacted with a base to produce a pyrrole represented by the formula:The pyrrole is reacted with a compound represented by the formula R3OC(O)N═C(Z)NHC(O)OR3or a derivative of carbamimidoic acid to provide a protected guanidine compound. The guanidine compound is converted to the desired deazaguanine by reaction with 1) trifluoracetic acid or 2) C1-C4alkoxide or alkali metal or alkaline earth metal hydroxide followed by neutralization with an acid.

REFERENCES:
patent: 5554615 (1996-09-01), Nomura et al.
patent: 6043365 (2000-03-01), McQuire et al.

Affiliated with

Also associated with

Rating

Process for the preparation of 9-deazaguanine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 9-deazaguanine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 9-deazaguanine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3427034