Process for the preparation of...

Details Process for the preparation of... Process for the preparation of...

2005-10-11

2005-10-11

Chang, Ceila (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S206000

Reexamination Certificate

active

06953856

ABSTRACT:
A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine hydrochloride (Donepezil HCl) is disclosed. 5,6-Dimethoxy-2-(pyridin-4-yl) methylene inda-1-one is hydrogenated with a noble metal catalyst or a non-oxide derivative of a noble metal catalyst in a solvent at 20-100° C. and 10-90 psi gauge pressure. The resulting 4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine is alkylated with an alkylating agent in an organic solvent at 20-80° C.

REFERENCES:
patent: 4895841 (1990-01-01), Sugimoto et al.
patent: 5606064 (1997-02-01), Lensky
patent: 6252081 (2001-06-01), Iimura
patent: WO 97/22584 (1997-06-01), None

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