Process for the preparation of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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Reexamination Certificate

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06908999

ABSTRACT:
The invention refers to a novel process for the preparation of {2-[-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl groups having 1 to 4 carbon atoms optionally substituted by a phenyl group, alkenyl groups having 2 to 4 carbon atoms or cyclohexyl groups, or the substituents together with the adjacent nitrogen atom of the acetoamido group, form a morpholino group.

REFERENCES:
patent: 4525358 (1985-06-01), Baltes et al.
patent: 5347060 (1994-09-01), Hellring et al.
patent: 6046332 (2000-04-01), Tao et al.
patent: 6140501 (2000-10-01), Duchene et al.
patent: 0 058 146 (1982-08-01), None
patent: WO-97/37982 (1997-10-01), None
Advanced Organic Chemistry (2nd. Ed.) by Jerry March, p. 353 (1977).
A Novel Synthesis of the Enantiomers of an Antihystamine Drug . . . by Opalka et al (SYNTHESIS vol. 7 1995).

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