Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-03-22
2005-03-22
Wilson, James O (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S028500, C536S028510, C536S028520, C536S028530, C536S028540, C536S028100, C536S025300, C536S025310
Reexamination Certificate
active
06870048
ABSTRACT:
The present invention is directed to the process for the preparation of 2′-deoxy-2′-halo-β-L-arabinofuranosyl nucleosides, and in particular, 2′-deoxy-2′-fluoro-β-L-arabinofuranosyl thymine (L-FMAU), from L-arabinose, which is commercially available and less expensive than L-ribose or L-xylose, in ten steps. All of the reagents and starting materials are inexpensive and no special equipment is required to carry out the reactions.
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Wright, J.A., et al. “Nucleosides. LX1AFluorocarbohydrates. XXII.1bSynthesis of 2-Deoxy-2-fluoro-D-arabinose and 9-(2-Deoxy-2-fluoro-α-and -β-D-arabinofuranosyl)adenines2”J. Org. Chem. 34(9):2632-2636, Sep. 1969.
King & Spalding LLP
Knowles, Esq. Sherry M.
Owens, Jr. Howard V.
Triangle Pharmaceuticals
Wilson James O
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