Process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphen

Details Process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphen Process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphen

1981-02-17

1982-06-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 544 28, C07D50104

Patent

active

043363768

ABSTRACT:
There is described a process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid in which a D(-)-p-hydroxy-N-(1-alcoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid salt is reacted with trimethylsilyl-2-oxazolidinone. The resulting reaction product is reacted in turn with an acyl chloride or an alkyl chloroformate to give a mixed anhydride which is reacted with a solution of 7-aminodesacetoxycephalosporanic acid prepared by silylation, in an anhydrous organic solvent, with trimethylsilyl-2-oxazolidinone.

REFERENCES:
patent: 4148817 (1979-04-01), Wright

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