Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2007-04-03
2007-04-03
Zucker, Paul A. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
Reexamination Certificate
active
10481704
ABSTRACT:
The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Raand Rcare each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rbis a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Raand Rcare each independently of the other hydrogen or a hydroxy-protecting group, and Rbis a carboxy-protective group
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Beilstein Database;Beilstein Institut zur Foerderung der Chemischen Wissenschaften, Beilstein database No. XP-002199750; [Marie-Pierre Heck, Alain Wagner, and Charles Mioskowski,Conversion of Primary Amides to Nitriles by Aldehyde-Catalyzed Water Transfer, J. Org. Chem. 1996, vol. 61,. No. 19, pp. 6486-6487].
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Beilstein Database;Beilstein Institut zur Foerderung der Chemischen Wissenschaften, database No. XP-002186064; Beilstein Registry No. 1726574; 5 pages; 1957.
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Beilstein Database;Beilstein Institut zur Foerderung der Chemischen Wissenschaften, database No. XP-001038113;[R. Roy, et al.,Chemenzymatic Synthesis of A C5-Chiral Building Block: A Substrate Modification Approach, Tetrahedron Letters, vol. 28, No. 42, pp. 4935-4938, 1987].
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Beilstein Database;Beilstein Institut zur Foerderung der Chemischen Wissenschaften, database No. XP-000608146; [P. L. Brower, et al.,The Synthesis of(4r-Cis)-1, 1-Dimethylethyl 6-Cyanomethyl-2,2-Dimethyl L-1,3-Dioxane-4-Acetate, A Key Intermediate for the Preparation of CI-981, A Highly Potent, Tissue Selective Inhibitor of HMG-COA Reductase, Tetrahedron Letters, vol. 33, No. 17, pp. 2279-2282, Apr. 21, 1992].
Baisch Gabriele
Bienewald Frank
Burkhardt Stephan
Kirner Hans Jörg
Öhrlein Reinhold
Kenyon & Kenyon LLP
Teva Pharmaceutical Industries Ltd
Zucker Paul A.
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