Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-07-08
1988-08-30
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540219, 540330, C07D20508, A61K 31545
Patent
active
047678518
ABSTRACT:
An improved process is disclosed for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins in which the corresponding 6-substituted amino penicillin sulphoxide is heated in the presence of an acidic substance which causes expansion of the penam ring in the reactant to the .DELTA..sup.3 cephem ring in the product in the presence of a silicon containing compound. The process comprises adding sulphamide or a silylsulphamide or a silylsulphamoyl to the reaction or utilizing a silylsulphamide or silylsulphamoyl as the silicon containing compound.
REFERENCES:
patent: 4003894 (1977-01-01), Verweij et al.
patent: 4159267 (1979-06-01), Cheu
GEMA, S.A.
Rizzo Nicholas S.
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