Process for the preparation of 7-amino and 7-substituted amino-d

Details Process for the preparation of 7-amino and 7-substituted amino-d Process for the preparation of 7-amino and 7-substituted amino-d

1985-07-08

1988-08-30

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540219, 540330, C07D20508, A61K 31545

Patent

active

047678518

ABSTRACT:
An improved process is disclosed for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins in which the corresponding 6-substituted amino penicillin sulphoxide is heated in the presence of an acidic substance which causes expansion of the penam ring in the reactant to the .DELTA..sup.3 cephem ring in the product in the presence of a silicon containing compound. The process comprises adding sulphamide or a silylsulphamide or a silylsulphamoyl to the reaction or utilizing a silylsulphamide or silylsulphamoyl as the silicon containing compound.

REFERENCES:
patent: 4003894 (1977-01-01), Verweij et al.
patent: 4159267 (1979-06-01), Cheu

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