Process for the preparation of 6-O-methyl erythromycin a using 9

Details Process for the preparation of 6-O-methyl erythromycin a using 9 Process for the preparation of 6-O-methyl erythromycin a using 9

1997-12-16

1999-04-06

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 72, C07H 100, C07H 1708

Patent

active

058920080

ABSTRACT:
The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4"-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.

REFERENCES:
patent: 4331803 (1982-05-01), Watanabe et al.

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