Process for the preparation of 6-demethyl-6-deoxy-6-methylene-te

Details Process for the preparation of 6-demethyl-6-deoxy-6-methylene-te Process for the preparation of 6-demethyl-6-deoxy-6-methylene-te

1974-09-24

1976-06-08

Davis, C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10322

Patent

active

039623300

ABSTRACT:
The invention relates to the preparation of 6-demethyl-6-deoxy-6-methylene-tetracycline by means of reductive dehalogenation of the corresponding 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline, the reaction being carried out in presence of the stoichiometric quantity of a tertiary phosphine, arsine or stibine and in a polar solvent. The time and temperature of the reaction are controlled within specified limits to obtain a complete conversion.

REFERENCES:
patent: 3250809 (1966-05-01), Blackwood et al.
patent: 3649700 (1972-03-01), Baader et al.
patent: 3659006 (1972-04-01), Pande
Borowitz et al., JACS, 94:19, Sept. 20, 1972, pp. 6817-6822.

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