Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-

Details Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5- Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-

1984-08-31

1987-04-21

Hollrah, Glennon H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603511, C07C10319

Patent

active

046595155

ABSTRACT:
The invention relates to a new and improved process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and the 11a-chloro derivative thereof by dehydrating 11a-chloro-5-oxytetracycline-6,12-hemiketal, which comprises treating 11a-chloro-5-oxytetracycline-6,12-hemiketal or an acid salt thereof with a dehydrating mixture formed by the reaction of chloro sulfonic acid and formic acid and isolating the 11a-chloro-6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and salt thus obtained and optionally dehalogenating the same by reaction with a reducing agent.
The advantage of the process of the present invention is that it is simple, economical and suitable for industrial scale manufacture and provides a pure product of high quality by excellent yields.

REFERENCES:
patent: 2984686 (1961-05-01), Blackwood et al.
patent: 3200149 (1965-08-01), Blackwood et al.
Merck Index, 9th Edition, 1976.

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