Process for the preparation of 6-alkoxy-substituted penicillins

Details Process for the preparation of 6-alkoxy-substituted penicillins Process for the preparation of 6-alkoxy-substituted penicillins

1976-07-13

1977-09-27

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D49944, C07D49958

Patent

active

040511260

ABSTRACT:
An improved process of preparing a 6-alkoxy-substituted penicillin or penicillin sulfoxide is disclosed. This process comprises adding a halogenating agent to penicillin or penicillin sulfoxide while cooling, and then adding an alkali metal alcoholate to the hydrogenation product in the presence of an alcohol corresponding to the alcoholate.

REFERENCES:
patent: 3778432 (1973-12-01), Pines
patent: 3843641 (1974-10-01), Christensen et al.
patent: 3994885 (1976-11-01), Koppel
J.A.C.S. 94, 1408-1411 (1972).
J.A.C.S. 95, 2403 (1973).
J.A.C.S. 95, 2401 (1973).
Weygond, "Preparative Organic Chemistry".

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