Process for the preparation of 6,7-diacyl-7-deacetylforskolin de

Details Process for the preparation of 6,7-diacyl-7-deacetylforskolin de Process for the preparation of 6,7-diacyl-7-deacetylforskolin de

1995-05-16

1997-03-11

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31192

Patent

active

056103158

ABSTRACT:
This invention relates to a process for the preparation of a 6,7-diacyl-7-deacetylforskolin derivative represented by the general formula: ##STR1## wherein R.sup.1 and R.sup.2 each stands for an acyl group and R.sup.3 stands for an aliphatic group having 2 to 3 carbon atoms, which comprises eliminating the acyl group at position 1 in a 1,6,7-triacyl-7-deacetylforskolin derivative represented by the general formula: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, by solvolysis. The compound of the formula (I) is expected as medicine.

REFERENCES:
patent: 4088659 (1978-05-01), Bhat et al.
patent: 4134986 (1979-01-01), Bajwa et al.
patent: 4639443 (1987-01-01), Kosley, Jr. et al.
patent: 4639446 (1987-01-01), Kosley, Jr. et al.
Sujata V. Bhat, Journal of the Chemical Society, Perkins Transactions I, pp. 767-771 (Mar. 1982).
Bhat, "The Antihypertensive and Positive Inotropic Diterpene Forskolin: Effects of Structural Modifications on its Activity, Journal of Medical Chemistry," 26:486-492 (1983).
Metzger et al., "The Positive Inotropic-Acting Forskolin, a Potent Adenylatecyclase Activator", Arzneimittel-Forschung, 31:1248-1250 (1981).
Bhat, Jes, Perkins Transactions I, pp. 767-771 (1982).

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