Process for the preparation of 5-substituted isobenzofurans

Details Process for the preparation of 5-substituted isobenzofurans Process for the preparation of 5-substituted isobenzofurans

2007-01-23

2007-01-23

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10776625

ABSTRACT:
There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5 isobenzofurancarbaldoxime, O-substituted preferably with a diphenylmethyl or triphenylmethyl group, with formic-acetic anhydride. Furthermore, the total synthesis of citalopram, as free base or in form of its pharmaceutically acceptable salt, starting from 5-formylphthalide is described.

REFERENCES:
patent: 02/48133 (2002-06-01), None

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