Process for the preparation of 5-substituted 2-chloropyridines

Details Process for the preparation of 5-substituted 2-chloropyridines Process for the preparation of 5-substituted 2-chloropyridines

1996-01-11

1997-07-15

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21361

Patent

active

056484950

ABSTRACT:
The present invention relates to a process for the preparation of 5-substituted 2-chloropyridines of the formula (I) ##STR1## by reaction of acetenamides of the formula (II) ##STR2## with Vilsmeier reagent, which is prepared by reaction of dialkylformamides of the formula (III) ##STR3## with a chlorinating agent, the excess of which is removed from the reaction mixture by distillation or by addition of dialkylformamide after completion of the reaction of the Vilsmeier reagent with the acetenamide of the formula (II), wherein in the formulae (I)-(III):

REFERENCES:
patent: 4504664 (1985-03-01), Nelson et al.
patent: 5099025 (1992-03-01), Kaufmann et al.
patent: 5304651 (1994-04-01), Lantzsch
patent: 5420284 (1995-05-01), Kraus
Chemical Abstracts, abstract No. 158,984b, abstract of DE 4,005,115, (1991).
O. Meth-Cohn, et al., J. Chem. Soc. Perkin Trans. I, pp. 1173-1182, (1984).
Derwent Database, AN 66-31844f, abstract of SU-193519, (1966).

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