Process for the preparation of 5-phenylsulfinyl-1H-2-(methoxycar

Details Process for the preparation of 5-phenylsulfinyl-1H-2-(methoxycar Process for the preparation of 5-phenylsulfinyl-1H-2-(methoxycar

1987-07-31

1988-12-20

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23530, C07D23532

Patent

active

047926104

ABSTRACT:
A highly selective, inexpensive and quantitative process is described for the preparation of 5-phenylsulfinyl-1H-2-(methoxycarbonylamino)-benzimidazole (oxfendazole) through reaction of 5-phenylmercapto-1H-2-(methoxycarbonylamino)-benzimidazole with hydrogen peroxide in the presence of one or more aliphatic C.sub.1 -C.sub.6 -alcohols with addition of a strong, nonoxidizing mineral acid.

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patent: 3929822 (1975-12-01), Beard et al.
patent: 3929824 (1975-12-01), Beard et al.
patent: 4197307 (1980-04-01), Gallay et al.
patent: 4255431 (1981-03-01), Junggren et al.
AA:Undheim et al., Acta Chem. Scand., 24, No. 9 (1970), 3429-3430.
Hoggarth, The Preparation and Reactivity, etc., J. Chem. Soc. 1949, pp. 3311-3315.

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