Process for the preparation of 5-oxohexane nitriles and the comp

Details Process for the preparation of 5-oxohexane nitriles and the comp Process for the preparation of 5-oxohexane nitriles and the comp

1992-06-24

1993-10-19

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558440, 546348, C07C25330

Patent

active

052547124

ABSTRACT:
The invention relates to a process for the preparation of high yields of 5-oxohexane nitriles with minimum formation of 1 undesired isomer. Such nitriles may be utilized as starting materials for the preparation of pharmaceutical and agrochemical intermediates and as well as final products. The process comprises reacting a methyl ketone and an .alpha.,.beta.-unsaturated nitrile in the presence of a catalytically effective amount of a strong base. One of the products which may be created by the process is 2,4-dimethyl-5-oxohexane nitrile.

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