Process for the preparation of 5-formylaminopyrimidines

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544298, 544322, 544323, 544333, C07D23950

Patent

active

056484909

ABSTRACT:
Disclosed is a process for the preparation of 5-formylaminopyrimidines of the general formula: ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are the same or different and signify H, OH, SH, NH.sub.2, alkylamino, halogen, O-alkyl, S-alkyl or alkyl, as well as aryl, and alkyl is an aliphatic radical containing up to 4 carbon atoms, from the corresponding 5-nitrosopyrimidines of the general formula: ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 have the same meanings as above, wherein the starting compound is subjected to a reductive formylation in the presence of a noble metal catalyst, as well as of formic acid and of a salt thereof.

REFERENCES:
patent: 4948890 (1990-08-01), Schneider
Laurent Fraisse et al., Long-Chain-Substituted Uric Acid and 5,6-Diaminouracil Derivatives as Novel Agents Against Free Radical Proceses: Synthesis and in Vitro Activity, Sep. 22 1992, pp. 1465-1473.
J. Medicinal Chemistry, 1993, vol. 36.
A. Yamazaki, Synthesis of 9-(4'Hydroxybutyl)-2-amino-6-hydroxy-purine 4'-Phosphate') Apr. 1969, pp. 1268-1270, Chem. Pharm. Bull. 17(6), 1969.
Shinozuka et al., Nucleoside Complexing . . . Synthetic Betains, 1985, pp. 141-150. Inorganic Chimica Acta, vol. 100, 1985.
J.C. Sircar et al., 8-amino-9-substituted guanines: Potent purine nucleoside phosphorylase (PNP) inhibitors, 1987, pp. 253-256. Agent and Action vol. 21.
Corbett et al. J. Org. Chem. 46(2), pp. 466-468 1981.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for the preparation of 5-formylaminopyrimidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 5-formylaminopyrimidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 5-formylaminopyrimidines will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1493213

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.