Process for the preparation of 5-fluoropyrimidines

Details Process for the preparation of 5-fluoropyrimidines Process for the preparation of 5-fluoropyrimidines

1992-02-13

1992-09-08

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23930

Patent

active

051459612

ABSTRACT:
5-Fluoropyrimidines are obtained in an advantageous manner from halogenated 5-unsubstituted pyrimidines, when these are reacted with elemental fluorine in the presence of a solvent.

REFERENCES:
patent: 3314955 (1967-04-01), Boudakian et al.
patent: 4786733 (1988-11-01), Van Der Puy et al.
Journal of Fluorine Chemistry, vol. 25, 1984; pp. 435-446; M. M. Boudakian et al.: `Substitutive Aromatic Fluorination with Chlorine Pentafluoride`, pp. 438, 444.

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