Process for the preparation of 5,6,7,8-tetrahydrofolic acid

Details Process for the preparation of 5,6,7,8-tetrahydrofolic acid Process for the preparation of 5,6,7,8-tetrahydrofolic acid

1985-10-10

1987-05-12

Rosen, Sam

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D47504

Patent

active

046651764

ABSTRACT:
A process for the preparation of 5,6,7,8-tetrahydrofolic acid which comprises dissolving and/or suspending folic acid or dihydrofolic acid in an aqueous solution containing an inorganic base, and bringing the resulting solution or suspension into contact with hydrogen in the presence of a noble metal catalyst while maintaining its pH at 5-9, thereby catalytically hydrogenating the folic acid of dihydrofolic acid into 4,5,6,7-tetrahydrofolic acid.

REFERENCES:
patent: 3870719 (1975-03-01), Knott
patent: 4540783 (1985-09-01), Viscontini
patent: 4595752 (1986-06-01), Azuma
O'Dell, J. Amer. Chem. Soc., 69, pp. 250-253, (1947).

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