Process for the preparation of 5-(4-amino butyl)-hydantoin and/o

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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260553R, C07C12715, C07D23376

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active

041580958

ABSTRACT:
An improved process for the preparation of 5-(4-aminobutyl)-hydantoin and/or 2-ureido-6-amino-hexanoic acid amide by the liquid phase hydrogenation of 5-(3-cyanopropyl)-hydantoin and/or 2-ureido-5-cyano-pentanoic acid amide in the presence of ammonia, hydrogen and a hydrogenation catalyst. Catalyst dissolution into the reaction medium is reduced by utilizing a hydrogenation catalyst in a solid bed form and causing the compounds to be hydrogenated to pass through such solid bed catalyst.

REFERENCES:
patent: 3461167 (1969-08-01), Buehler et al.
patent: 3758494 (1973-09-01), Suverkropp et al.
patent: 4007226 (1977-02-01), Reynolds
patent: 4119782 (1978-10-01), Konijnenberg et al.

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