Process for the preparation of 5-(2,4-difluorophenyl)-salicylic

Details Process for the preparation of 5-(2,4-difluorophenyl)-salicylic Process for the preparation of 5-(2,4-difluorophenyl)-salicylic

1991-12-27

1994-05-17

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562418, 562423, 562469, 562492, 562477, 562474, 562475, 568637, 568638, 568639, 568642, 568643, 568746, 560141, 548215, C07C 5115, C07C 4124, C07C 4101

Patent

active

053129750

ABSTRACT:
A process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid comprising the reaction of an organometallic derivative with a suitable substituted benzene in the presence of a transition-metal based catalyst is described.

REFERENCES:
patent: 3992459 (1976-11-01), Utne et al.
patent: 4225730 (1980-09-01), Jones et al.
patent: 4486599 (1984-12-01), Meneghin et al.
Journal of Organic Chemistry, Chemical Communications, vol. 42, No. 10, 1977, pp. 1821-1823, S. Danishefsky, et al., "Selective Carbon-Carbon Bond Formation via Transition Metal Catalysis.3..sup.1, A Highly Selective Synthesis of Unsymmetrical Biaryls and Diarylmethanes By the Nickel- Or Palladium-Catallyzed Reaction of Aryl-and Benzylzinc Derivatives With Aryl Halides".
Organic Syntheses, vol. 66, 1988, pp. 67-74, E. Negishi, et al., "Synthesis of Biaryls via Palladium-Catalyzed Cross Coupling: 2-Methyl-4'-Nitrobiphenyl (1,1'-Biphenyl", 2-methyl-4'-nitro-).
J. March, Advanced Organic Chemistry--Reactions, Mechanisms, and Structure, 3rd ed., John Wiley & Sons, Inc., U.S.: 1985, p. 425.
The Merck Index, ed. 11, Merck & Co., Inc., New Jersey, U.S.: 1989, p. 3131, No. 3130, "Difllunisal".
The Merck Index, ed. 11, Merck & Co., Inc., New Jersey, U.S.: 1989, pp. 4879, No. 4878, "Infusorial Earth".

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