Process for the preparation of 4-oxytetrahydropyran-2-ones

Details Process for the preparation of 4-oxytetrahydropyran-2-ones Process for the preparation of 4-oxytetrahydropyran-2-ones

2006-08-22

2006-08-22

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07094912

ABSTRACT:
A process for the preparation of inhibitors of HMG-CoA reductase, such as simvastatin, from 4-silyloxytetrahydropyran-2-ones with triethylamine trihydrofluoride being used as the desilylation reagent is described. The reaction is performed in organic solvents, a mixture thereof or without solvents. It is characteristic of this reaction that no additional impurities are obtained and that it takes place without the use of additional catalysts and with low excesses of the reagent.

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