Process for the preparation of 4-methyl-7-aminoquinolones

Details Process for the preparation of 4-methyl-7-aminoquinolones Process for the preparation of 4-methyl-7-aminoquinolones

2006-12-05

2006-12-05

Powers, Fiona T. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Azo

C534S768000, C534S771000, C546S153000, C562S053000, C564S200000

Reexamination Certificate

active

07144993

ABSTRACT:
The present invention relates to a process for the preparation of a compound of the general formula (I), which comprises converting a compound of the general formula (II), in an aprotic organic solvent in the presence of a catalytically active amount of a strong acid (catalyst) or of an agent that liberates a strong acid or of an ammonium salt of a strong acid, it also being possible for the catalyst to be part of the starting material/product, into a compound of formula I, wherein R5, R6and R8are each independently of the others a hydrogen atom, a nitro group, a sulfo group, a halogen atom, a pseudohalogen, a group COOR1or CONHR2or a C1-8alkyl, C1-8alkoxy or aryloxy radical, an amide group, a thioalkyl or thioaryl radical, an alkyl- or aryl-sulfonyl radical, an alkyl- or aryl-sulfinyl radical, a trifluoromethyl group or a phosphono group, R1and R2being a hydrogen atom or a C1-8alkyl radical or an aryl or aralkyl radical, R10is a group —C(O)CH2C(O)CH3and R11is a hydrogen atom or an acyl radical, or R10and R11are a group —C(O)CH2C(O)CH3. The process according to the invention is simple to perform and results in products of high chemical purity and high isomeric purity in a high yield

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