Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazoly

Details Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazoly Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazoly

1975-05-21

1976-05-18

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, 260304A, C07D27902

Patent

active

039577724

ABSTRACT:
A novel process for preparing 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (I), starting with 3-amino-5-methylisoxazole (II) is disclosed. Compound I exhibits anti-inflammatory properties and is useful for treating inflammation. In the process of the invention an intermediate obtained, 2,3-dihydro-N-(5-methyl-3-isoxazolyl)-3-oxo-1,2-benzisothiazole-2-acetamid e 1,1-dioxide (IV) undergoes rearrangement to provide 1-{[5-(4-hydroxy-2H-1,2-benzothiazin-3-yl)-1,2,4-oxadiazol-3-yl]methyl}eth anone S,S-dioxide (V), which is methylated, according to conventional procedures. The methylated intermediate VI, upon further treatment, undergoes a second rearrangement to obtain the desired anti-inflammatory compound I.

REFERENCES:
patent: 3787324 (1974-01-01), Zinnes et al.
patent: 3822258 (1974-07-01), Zinnes et al.
patent: 3868367 (1975-02-01), Zinnes et al.

Affiliated with

Also associated with

Rating

Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazoly does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazoly, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazoly will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2235120