Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-

Details Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3- Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-

1976-05-10

1978-02-14

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

260304R, 2602948D, 424246, C07D27902, C07D41712

Patent

active

040740480

ABSTRACT:
A novel process for preparing 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides is disclosed. The process involves the base catalyzed rearrangement of a saccharinacetamide of structure I to give II, ##STR1## wherein R.sup.1 is hydrogen or lower alkyl and R.sup.2 is lower alkyl, aryl or a heterocyclic ring selected from the group consisting of pyridyl, substituted-pyridyl, and thiazolyl. Compounds of the formula II have useful anti-inflammatory properties. In addition, they can be used as intermediate in the preparation of known anti-inflammatory agents.

REFERENCES:
patent: 3284450 (1966-11-01), Kraaijeveld et al.
patent: 3492296 (1970-01-01), Zinnes et al.
patent: 3501466 (1970-03-01), Rasmussen
patent: 3957772 (1976-05-01), Fabian et al.

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