Process for the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H

Details Process for the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H Process for the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H

1983-06-29

1984-10-02

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D40112

Patent

active

044749562

ABSTRACT:
In the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H-benzothiazine-3-carboxamide 1,1-dioxide by reacting the corresponding 3-methoxycarbonyl compound with 2-aminopyridine, a dramatic increase in the yield is obtained if the reaction is carried out in the presence of 0.1 to 1.5 mole equivalent (based on the 3-methoxycarbonyl compound) of an alkyl- or arylsulfonic acid.

REFERENCES:
patent: 3501466 (1970-03-01), Rasmussen
patent: 3891637 (1975-06-01), Lombardino
patent: 4100347 (1978-07-01), Hammen
patent: 4309427 (1982-01-01), Lombardino

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