Process for the preparation of 4-hydroxy-2,4,6-trimethyl-2,5-cyc

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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C07C 4530

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045608016

ABSTRACT:
4-Hydroxy-2,4,6-trimethyl-2,5-cyclohexadienone is prepared by treatment of 2,4,6-trimethylphenol with a halogenation agent and water in the presence of an organic solvent which is inert to the halogenation agent.

REFERENCES:
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patent: 2903487 (1959-09-01), Coffield
patent: 3895069 (1975-07-01), Atkinson et al.
patent: 3928453 (1975-12-01), Atkinson
patent: 4477682 (1984-10-01), Tomita et al.
Fieser et al., "Reagents for Organic Synthesis", pp. 487-489, _John Wiley & Sons, Inc., (1973).
Can. J. Chem., Alfred Fischer and George N. Henderson, "IPSO _Chlorination of 4-Alkylphenols. Formation of 4-Alkyl-Chlorocyclohexa-2-5-Dienones", pp. 552-557.
Acta Chemica Scandinavica B 36 (1982) 675-683, Karl Erik Berquist, Anders Nilsson and Alvin Ronlan, "Electrophilic Chlorination of 4-Methylphenols with Molecular Chlorine", etc.

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