Process for the preparation of 4-hydroxy-1,2,2,6,6,-pentamethylp

Details Process for the preparation of 4-hydroxy-1,2,2,6,6,-pentamethylp Process for the preparation of 4-hydroxy-1,2,2,6,6,-pentamethylp

1993-03-18

1998-11-24

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546242, C07D21144

Patent

active

058409050

ABSTRACT:
A process for the preparation of 4-hydroxy-1,2,2,6,6-pentamethylpiperidine (HPMP) from 4-oxo-2,2,6,6-tetramethylpiperidine (TAA) is described, in which TAA is first reduced to 4-hydroxy-2,2,6,6-tetramethylpiperidine (HTMP) by means of catalytic hydrogenation in water, the resulting crude solution, if desired after concentration by distillation, is reacted with formaldehyde or paraformaldehyde in at least 20% molar excess, and with formic acid, and the crude product melt separated from the reaction mixture is worked up by distillation.

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patent: 4921962 (1990-05-01), Galbo et al.
Helv. Chim. Acta, 49 (1), 690-695 (1966).
L. Zhelyazkov a nd N. Bikova, Farmatsiya (Sofia), 13, 11 (1963) English Translation.
Chemical Abstracts, vol. 60 (3), Abst. No. 2881-e-g Feb. 03, 1964.

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