Process for the preparation of 4-haloquinazolines

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544286, C07D23972

Patent

active

052141446

ABSTRACT:
4-Haloquinazolines can be prepared by the halogenation of the corresponding 4-hydroxyquinazolines with a phosphoryl, thionyl or carbonyl halide in the presence of a catalytically effective amount of a N,N-dialkylformamide. The reaction is catalyzed by the addition of soluble organic halide salts.

REFERENCES:
patent: 1880447 (1932-10-01), Hentrich et al.
patent: 3505331 (1970-04-01), Hitchings et al.
patent: 4672116 (1987-06-01), Bandurco et al.
Anderson et al., Synthesis, 1976, 398-399.
Botta et al., Journal of Heterocyclic Chemistry, 26 (1989) 883-4.
Brown, The Pyrimidines, Supplement I, pp. 116-117, R3 (1970).
Fieser & Fieser pp. 284-289 (1967).
Amarego J. Appl. Chem. 11 pp. 70-72, (1961).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for the preparation of 4-haloquinazolines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 4-haloquinazolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 4-haloquinazolines will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-898096

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.