Process for the preparation of 4'-deoxy-daunorubicin and 4'-deox

Details Process for the preparation of 4'-deoxy-daunorubicin and 4'-deox Process for the preparation of 4'-deoxy-daunorubicin and 4'-deox

1981-06-05

1982-08-17

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1524

Patent

active

043450709

ABSTRACT:
A new process for the preparation of the known 4'-deoxydaunorubicin and 4'-deoxydoxorubicin is disclosed. The used starting material is 4'-eip-N-trifluoroacetyldaunorubicin which is converted into 4'-deoxy-4'-iodo-N-trifluoroacetyl-daunorubicin from which 4'-deoxy-daunorubicin can be reductively obtained and eventually transformed, by known methods, into 4'-deoxy-doxorubicin.

REFERENCES:
patent: 3886138 (1975-05-01), Naito et al.
patent: 4067969 (1978-01-01), Penco et al.
patent: 4112076 (1978-09-01), Arcamone et al.
patent: 4156078 (1979-05-01), Umezawa et al.

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