Process for the preparation of 4-carboxy-5, 8,11-tris (carboxyme

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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562470, Z07C22928, Z07C 5948

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active

061629472

ABSTRACT:
A novel a process for the preparation of the chelating agent of formula (I) ##STR1## 4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecan- 13-oic acid, commonly named BOPTA.

REFERENCES:
patent: 2820816 (1958-01-01), Anspon
patent: 5182370 (1993-01-01), Felder et al.
Aime et al Inorganic Chemistry, vol. 31, No. 6, Mar. 1992 pp. 1100-1103 XP002120082 "Synthesis and NMRD Studies of GD.sup.3+ Complexes of Macrocyclic Polyamino Polycarboxyilic Ligands Bearing . . . "1992.
Grassman et al Chemische Berichte vol. 91, 1958, pp 538-541, XP002127665 "Darstellung und Peptidsynthetische Verwendung von O-Benzyl-serin".
Grassman et al., Chem. Ber., 1958, 91, pp. 538, 1958.

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