Process for the preparation of 4-benzyl aspartate

Details Process for the preparation of 4-benzyl aspartate Process for the preparation of 4-benzyl aspartate

1986-06-09

1987-11-24

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C10122

Patent

active

047090863

ABSTRACT:
In the process for the preparation of 4-benzyl aspartate starting from dibenzyl aspartate and/or its salts only one benzyl group is selectively removed by catalytic hydrogenation. By setting up appropriate reaction conditions elimination takes place mainly of the benzyl group on the C.sub.1 atom of the compound. The desired product can be isolated from the reaction mixture by precipitation.

REFERENCES:
patent: 4394308 (1983-07-01), Sampathkumar et al.
Levenspiel, "Chemical Reaction Engineering," 2nd Ed., pp. 185-199, (1972).
McOmie, "Protective Groups in Organic Chemistry," pp. 196-198 & 210-215, (1973).
Smith, J. Pharm. Sci., 54, pp. 1269-1273, (1965).
Heeswijk, Synthesis, pp. 744-747, (1982).
Howben-Weyl, 15/1, p. 349, (1974).
Prestidge, J. Org. Chem., 40, pp. 3287-3288, (1975).

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