Process for the preparation of 4-amino-androstenedione derivativ

Details Process for the preparation of 4-amino-androstenedione derivativ Process for the preparation of 4-amino-androstenedione derivativ

1988-05-10

1989-09-12

Robinson, Douglas W.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 100

Patent

active

048657662

ABSTRACT:
A process for the preparation of 4-aminoandrostenediones of formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein one of R.sub.1 and R.sub.2 is hydrogen and the other is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl, and the symbol indicates that each of (x) and (y), independently, is a single bond or a double bond, comprising reacting a compound of formula (II) ##STR2## wherein E is a halogen atom and R.sub.1, R.sub.2, (x) and (y) each are as defined as above with ammonia.

REFERENCES:
patent: 4757061 (1988-07-01), Faustini et al.

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