Process for the preparation of 4, 6- dihydroxypyrimidine

Details Process for the preparation of 4, 6- dihydroxypyrimidine Process for the preparation of 4, 6- dihydroxypyrimidine

1997-06-30

1998-12-08

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23952

Patent

active

058471391

ABSTRACT:
The invention relates to a process for the preparation of 4,6-dihydroxypyrimidine by reacting malonate with formamide and an alkali metal alkoxide at elevated temperature. In this process, the malonate alone or simultaneously with all or some of the formamide is added in portions or continuously to the alkali metal alkoxide initially introduced as a solution or suspension in an alcohol alone or together with all, or the remainder, of the formamide.

REFERENCES:
B.A. Zasonov, et al., Khim. Farm. ZH., vol. 8, No. 12, pp. 28-31, 1974, "Synthesis of 4-(N-Aminobenzolsulphamido)-6-Methoxypyrimidine (Russian)".
D.J. Brown, Journal of Chemical Society, pp. 2312-2314, 1956, "Pyrimidine Reactions. Part I. Pyrimidines from Malondiamide".
Claude Hennart, et al., Bulletin De La Societe Chimique De France, pp. 741 and 742, 1959, "Contribution A La Synthese De La Dichloro-4.6-Pyrimidine".
R. Hull, Journal of Chemical Society, 1951, "A New Synthesis of 4:6-Dihydroxypyrimidines".

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