Process for the preparation of 4,5-difluoroanthranilic acid from

Details Process for the preparation of 4,5-difluoroanthranilic acid from Process for the preparation of 4,5-difluoroanthranilic acid from

1990-06-04

1991-02-19

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562479, 562458, C07C22900

Patent

active

049946064

ABSTRACT:
4,5-Difluoroanthranilic acid may be prepared by decarboxylating 4,5-difluorophthalic anhydride or 4,5-difluorophthalic acid by heating in dimethyl acetamide, N-methyl-2-pyrrolidone or quinoline, optionally by reaction with copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst, whereby 3,4-difluorobenzoic acid is formed; nitrating said 3,4-difluorobenzoic acid in a mixture of nitric and sulfuric acids to form 2-nitro-4,5-difluorobenzoic acid, and reducing said 2-nitro-4,5-difluorobenzoic acid to form 4,5-difluoroanthranilic acid.

REFERENCES:
Graw, J. D. et al, J. Chem. Eng. Data 13(4), 587-588, 1968.

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