Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1989-07-05
1990-09-11
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568313, C07C 4562
Patent
active
049565052
ABSTRACT:
4,4-Dimethyl-1-(p-chlorophenyl)pentan-3-one can be prepared by condensation of pinacolone and p-chlorobenzaldehyde in an alcohol as solvent in the presence of an inorganic base and by subsequent hydrogenation, in which the reaction mixture obtained in the condensation is hydrogenated directly without isolation of the intermediate 4,4-dimethyl-1-(p-chlorophenyl)-1-penten-3-one after the addition of a hydrogenation catalyst at elevated temperature and superatmospheric pressure to give 4,4-dimethyl-1-(p-chlorophenyl)pentan-3-one, after the hydrogenation catalyst has been separated off from the liquid hydrogenation mixture, the alcohol is largely distilled off, and the water content of the bottom product of the distillation is adjusted in such a manner that it separates into an aqueous and an organic phase, and the 4,4-dimethyl-1-(p-chlorophenyl)pentan-3-one is recovered from the organic phase.
REFERENCES:
patent: 4041083 (1977-08-01), Gradiff et al.
patent: 4221741 (1980-09-01), Gaster
patent: 4239657 (1980-12-01), Nissen et al.
Gillespie et al., Tetrahedron, vol. 31, pp. 3-8 (1975).
Fiege Helmut
Henneke Karl-Wilhelm
Mais Franz-Josef
Bayer Aktiengesellschaft
Reamer James H.
LandOfFree
Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)pe does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)pe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)pe will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1186033