Process for the preparation of 4-[2-(dimethylamino)-ethoxy]2-met

Details Process for the preparation of 4-[2-(dimethylamino)-ethoxy]2-met Process for the preparation of 4-[2-(dimethylamino)-ethoxy]2-met

1980-12-04

1982-06-22

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560109, 560131, 560142, 564354, C07C 7946, C07C 6742

Patent

active

043363962

ABSTRACT:
This invention relates to a process for the preparation of 4-[2-(dimethylamino)-ethoxy]-2-methyl-5-(1-methylethyl)-phenol esters (I) and their salts with organic and inorganic acids comprising the reaction of thymol with a salt of an 1-halo-dimethylaminoethane to obtain ethylamine-N,N-dimethyl-2-(thymyloxy) (II), the subsequent reaction of (II) with an acylating agent according to the Friedel and Kraft reaction to obtain 4-[2-(dimethylamino)-ethoxy]-2-methyl-5-(1-methylethyl)-1-acyl-benzene (III) and the oxidation of (III) to obtain the products (I) which, if desired, may be transformed in their salts with organic or inorganic acids.
This process allows to obtain the products (I) in high quality and quantity without isolating any intermediate product.

REFERENCES:
patent: 3966779 (1976-06-01), Satzinger

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