Process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-n

Details Process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-n Process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-n

1991-12-04

1992-08-25

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 19, C07C20500

Patent

active

051420937

ABSTRACT:
A process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-nitro-benzoate, an intermediate for the preparation of 5-(2,4-difluorophenyl)-salicylic acid, which is a drug known with the international non-proprietary name Diflunisal, is described.

REFERENCES:
patent: 4216109 (1980-08-01), Mizukuchi
patent: 4225730 (1980-09-01), Jones et al.
patent: 4486599 (1984-12-01), Meneghin et al.
Merck Index, XI Ed., No. 3130, p. 495, "Diflunisal" (1983).

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