Process for the preparation of 3-trifluoromethyl-and 2,5-dimethy

Details Process for the preparation of 3-trifluoromethyl-and 2,5-dimethy Process for the preparation of 3-trifluoromethyl-and 2,5-dimethy

1983-12-27

1986-06-03

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514811, A61K 31065

Patent

active

045930473

ABSTRACT:
The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications.
3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.

REFERENCES:
patent: 4094908 (1978-06-01), Toth et al.
Arzneimittelforschung, 28 (1), 4, 673-677 (1978).
Chem. Abstracts 92:52927b (1980) Szinai et al, Proc. 19th Hung. Ann. Meet, Biochem. 1979.

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