Process for the preparation of 3-substituted derivatives of 1-am

Details Process for the preparation of 3-substituted derivatives of 1-am Process for the preparation of 3-substituted derivatives of 1-am

1994-04-12

1995-02-21

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

549553, 549555, 549559, 564302, 564304, 564346, 564347, 564348, 564349, C07D295108, C07C21744, C07C21764

Patent

active

053917359

ABSTRACT:
The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new process of the invention.

REFERENCES:
patent: 2252039 (1941-08-01), Schirm
patent: 2977374 (1961-03-01), Phillips
patent: 3780081 (1973-12-01), Le Count
patent: 3987086 (1976-10-01), Dexter
patent: 4085136 (1978-04-01), Tucker
patent: 4120974 (1978-10-01), Frater
patent: 4171370 (1979-10-01), Jonas
patent: 4229449 (1980-10-01), Melloni
patent: 4263325 (1981-04-01), Carlsson
patent: 4341718 (1982-07-01), Kim
Banzatti et al., "Synthesis of Phenyl-substituted 2H-3,4-Dihydro-3-aminomethyl-1,4-benzoxazines", J. Heterocyclic Chem 20, 259-265(1983).

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